![]() ![]() ![]() Polledness in Nelore cattle is associated with one region in the genome with 3.1 Mb size in chromosome 1. In addition, a runs of homozygosity (ROH) analysis identified a ROH island in polled animals with 2.47 Mb inside the region identified by WssGWAS. The functional enrichment analysis by DAVID tool revealed cytokine-cytokine receptor interaction, JAK-STAT signaling, natural killer cell mediated cytotoxicity, and osteoclast differentiation pathways as significant (P < 0.05). A total of 28 protein-coding genes are mapped in this region, including the taurine Polled locus and the IFNAR1, IFNAR2, IFNGR2, KRTAP11-1, MIS18A, OLIG1, OLIG2, and SOD1 genes, which expression can be related to the horn formation as described in literature. A centromeric region of chromosome 1 with 3.11 Mb size (BTA1: 878,631–3,987,104 bp) was found to be associated with hornless in the studied population. The weighted single-step approach for genome-wide association study (WssGWAS) was used to estimate the SNP effects and variances accounted for by 1 Mb sliding SNP windows. A total of 107,294 animals had phenotypes recorded and 2,238 were genotyped/imputed for 777k SNP. ![]() The aim of this study was to identify genomic regions associated with the hornless trait in a commercial Nelore population. The expression of the polled trait is known to be ruled by a few groups of alleles in taurine breeds however, the genetic basis of this trait in indicine cattle is still unclear. The causal mutation for polledness in Nelore ( Bos taurus indicus) breed seems to have appeared first in Brazil in 1957. ![]()
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |